北京索莱宝科技有限公司 张净花 010-563671206

Collagen  from bovine achilles tendon


Product Description
Storage Temperature 2-8 °C
CAS Number: 9007-34-5
This product is suitable for use as a substrate for
collagenase.1 It is prepared by modification of the
method of Einbinder and Schubert and is not suitable
for use in coating glassware.2
This collagen is Bornstein and Traub Type I, not to be
confused with Sigmas catalog type which is an
organizational placeholder. The Type I classification
of collagen is a component of skin, bone, tendon, and
other fibrous connective tissues. Type I collagen
differs from other collagens by their low lysine
hydroxylation and low carbohydrate composition.
Collagen breaks down metabolically in the body to
release N-telopeptide, which is the N-terminus of
collagen. There is also C-telopeptide, which is
presumably the C-terminus. N-telopeptide is released
in urine, and its detection in diagnostic tests is used to
screen for osteoporosis.
Although different types of collagen exist, they are all
composed of molecules containing three polypeptide
chains arranged in a triple helical conformation. Slight
differences in the primary structure (amino acid
sequence) establish differences between the types.
The amino acid sequence of the primary structure is
mainly a repeating motif with glycine in every third
position and proline or 4-hydroxyproline frequently
preceeding the glycine residue.


Precautions and Disclaimer
For Laboratory Use Only. Not for drug, household or
other uses.
Preparation Instructions
This collagen preparation is insoluble in water,
aqueous buffers, and organic solvents.
References
1. von Hippel, P.H., et al., J. Am. Chem. Soc., 82,2774 (1960).
2. Einbinder, J. and Schubert, M.J., J. Biol.Chem.,188, 335 (1951).
3. Tanzer, M. L., Cross-linking of collagen. Science,180(86), 561-566 (1973).
4. Bornstein, P., and Sage, H., Structurally distinctcollagen types. Ann. Rev. Biochem., 49, 957-1003(1980)